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From mutation detection to highly sensitive cancer screenings, DiaCarta is advancing science through customized solutions.

Products Overview

QClamp® Gene Mutation Detection Kits on open qPCR Machines

DiaCarta’s QClamp® Gene Mutation Detection kits are real-time PCR based assays that use proprietary XNA (Xenonucleic acid) technology to block amplification of WT-DNA, allowing selective amplification of mutant DNAs. Blocking of WT-DNA amplification offers unparalleled sensitivity with minimum sample input. Assays are SYBR green based and can be run on any real-time PCR platform. QClamp® is ideal for DNA extracted from FFPE, liquid biopsy, traditionally challenging cytology samples (fine needle aspirates, effusions, CSF), and requires a minimal amount of DNA per assay. CE/IVD-cleared and cost effective, QClamp products are compatible with most PCR machines.

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QFusion™ Fusion Gene Tests

DiaCarta’s Fusion Gene Detection Kit are real-time PCR based assays that use proprietary XNA (Xenonucleic acid) technology (QClamp® Somatic Mutation Technology) to block amplification of WT-DNA, allowing selective amplification of mutant DNAs. Blocking of WT-DNA amplification offers unparalleled sensitivity with minimum sample input. Assays are SYBR green based and can be run on any real-time PCR platform. DiaCarta now offers targets of ALK, ROS1, RET T,  NTRK for research use only.

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DNA Sample Card

DiaCarta’s DNA sample card is designed for DNA extraction and preservation on saliva, blood (serum, whole blood), urine, feces, amniotic fluid, cervical fluid, tumor cells, plant leave marks and tissue homogenate. The card is ready to use and provide a simple way of DNA sample collection and identification. Shipment and storage can be handled at room temperature (no dry ice shipping or cold storage). Once collected, the DNA is stable, re-testable and archivable.

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QEx™ FFPE DNA PCR Ready Lysis Buffers

The QEx™ FFPE PCR ready lysis buffers are efficient and versatile for isolating  DNA from formalin-fixed paraffin-embedded (FFPE) samples. The unique chemistry of the QEx™ reagents preserves DNA in linear format and increases PCR and hybridization efficiency. The workflow is simple and fast with only 4 steps of adding and mixing the samples with buffer A and B sequentially. The whole procedure can be finished within 18 minutes with minimal manual operation. The lysate can be used directly in a wide range of downstream applications, i.e., PCR, real-time PCR and sequencing, etc.

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ColoScape™ Non-Invasive Colorectal Cancer Screening Test

DiaCarta has identified a proprietary molecular panel of genetic variations in several genes that have been classified as colorectal cancer-initiating events that are biomarkers for molecular detection of beginning cancer and its precursors. This molecular gene signature mutational panel is being used together with DiaCarta’s proprietary QClamp® XNA-PCR technology to detect tumor gene mutations in patient’s stool derived DNA.

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Dimerator™ Adapter Dimer Removal for NGS Library Preparation

Powered by XNA technology, Dimerator™ uses XNA clamps to block adapter-adapter ligation and improves adapter dimer to tagged library ratio, which lead to significantly higher quality sequencing data. This technology has solved the problem of formed dimer when 5’ and 3’ adapters self-ligate without library insert and requires no gel purification to remove dimer. It also prevent the amplification of the smaller dimer side product out-competes amplification of tagged library.

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CRISPR-Quest Gene Editing Tests

The research community’s rapid acceptance of the CRISPR/Cas9 technology is propelling a stage of deep investment in technology development. Already, three companies have emerged focusing on CRISPR therapeutic applications: Intellia Therapeutics, Editas Medicine, and CRISPR Therapeutics.

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DigiPlex Genotyping Test

DiaCarta DigiPlex™ Technology provides a platform for the digital multiplexing of proteins and DNA with barcoded beads and delivers more than 1,000-plex capabilities.

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