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DiaCarta technologies deliver faster, more sensitive results for diagnostic and molecular genetic testing.

Personalized CAR-T Immunotherapy Platform
Accelerate your cancer research and drug discovery

In the era of the Cancer MoonShot 2020 Program – the nation’s most comprehensive cancer collaborative initiative to accelerate the potential of combination immunotherapy as the next generation standard of care in cancer patients, DiaCarta and ProMab have joined hands to offer the next-generation Chimeric Antigen Receptor T-Cell (CAR-T) immunotherapy platform.

Platform overview

1500 Existing Hybridomas and Antibody Engineering

1500 Existing Hybridomas and  Antibody Engineering

Custom Lentiviral CAR Construction (GMP)

Custom Lentiviral    CAR Construction (GMP) 

High-Throughput Multiplex Cytotoxicity Assays

High-Throughput Multiplex Cytotoxicity Assays

In Vivo Efficacy and Toxicity Validation

In Vivo Efficacy and Toxicity Validation

CAR-T Cell Manufacturing (GMP)

CAR-T Cell Manufacturing (GMP)

Biomarker Discovery

Biomarker Discovery

Genomic Profiling

Genomic Profiling

Next-Generation Sequencing

Next-Generation Sequencing

CAR-T Infusion Treatment

CAR-T Infusion Treatment

Comprehensive Services

Genomic Profiling - Biomarker discovery and CAR-T profiling

  • Gene mutation analysis by QClamp® XNA-PCR
  • Gene expression by QuantiMarker™ assays
  • OptiSeq™next-generation sequencing
  • GLP and CLIA lab settings

Cytokines Assays - Bead-based multiplex protein tests run on Bio-Rad Bio-Plex®

  • Standard assays for cytokine detection in activated CAR-T cells (e.g. IL-2, IL-6, IFN-ϒ)
  • Customized assays for quantitating up to 50 cytokines
  • GLP and CLIA lab settings

CAR-T Services - Focus on generating CAR for murine-based pre-clinical studies or use as a clinical tool

  • Antibody discovery (hybridomas, mouse, rabbit and human library)
  • Customized lentiviral CAR construction
  • CAR-T cell manufacturing
  • Real-time cytotoxicity assay (RTCA)
  • Multiplex cytokine screening
  • Mouse in vivo efficacy and toxicology modeling
  • In vivo imaging by Xenogen/PerkinElmer IVIS system
  • GMP manufacturing of CD3/CD28 beads (coming soon)
  • GMP manufacturing of lentiviral CAR (coming soon)
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