Detecting BRAF (V600E) Mutation in FFPE or Blood Samples
When mutated, oncogenes can convert normal cells to cancer cells. BRAF is one of the oncogenes that controls transduction of chemical signal from outside the cells to nucleus. As a member of the RAS/MAPK pathway, the BRAF gene product, the B-Raf protein, regulates cell growth and division.
BRAF (V600E) mutation, the most common BRAF mutation, has been found in different types of cancer including melanoma, colon cancer, and hairy cell leukemia. BRAF mutations occur between 40 and 60% of melanoma and 90% of these mutations are V600E. It has been shown BRAF (V600E) is more sensitive to BRAF inhibitors and some of these inhibitors have demonstrated clinical efficacy for malignant melanoma metastasis and increase patient overall survival. Identification of the BRAF (V600E) mutation may provide benefits to the patients who are selected for BRAF inhibitor therapy.
Using the XNA technology, we have developed gene mutation detection kits to identify BRAF (V600E) and other important cancer driver genes using a simple and fast qPCR assay that regular qPCR can’t do. We recently have also celebrated our 7th anniversary and reward our researchers with these mutation kits.
NGS test for colorectal cancer to guide targeted therapy
Colorectal cancer (CRC) can develop from germline genetic mutations inherited from family or somatic mutations developed later in life. Our Optiseq™ colorectal cancer NGS for mutation detection panel covers genes associated with both hereditary and somatic mutations...
Detection of ROS1, RET, and ALK fusions in non-small cell lung cancer
ROS1 (c-ros oncogene 1), RET (rearranged during transfection), and ALK (anaplastic lymphoma kinase) are receptors of tyrosine kinases that play important roles in cell growth and differentiation. ROS1, RET or ALK fusion is formed by chromosomal rearrangements that...
Who should be tested for VEXAS syndrome?
As a relatively newly discovered autoinflammatory disease, VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is associated with mutations in the UBA1 gene. Diagnosis of the disease relies on the testing of genetic mutation in patients. What are...
Genetic Testing for the VEXAS Syndrome
Diagnosis of the VEXAS syndrome improves medical management of the disease and provides more effective treatment of the disease, although there is no cure currently. The diagnosis relies on the VEXAS syndrome genetic testing, a test for a mutation present in the UBA1...
What is VEXAS syndrome?
VEXAS syndrome, which stands for "Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic," is a rare and recently identified, chronically progressive autoinflammatory disorder. It was first described by Dr. Beck in a study published in the New England Journal of...
Dealing with the Respiratory Viruses that Cause Covid-19 or Flu
Influenza and COVID-19: what are they in common? Currently, the two most important respiratory viruses the healthcare authority is paying attention to are SARS-COV-2 (causing COVID-19) and influenza A and B viruses (Flu A and B). The Flu A and B viruses (named by the...