Abstract: Both U:G and T:G lesions in formalinfixed tissue are sources of false-positive EGFR T790M mutations. This is the first report of the use of TDG to reduce sequence artifacts in formalin-fixed DNA and is applicable to the accurate detection of mutations arising at methylated cytosines. Authors: Hongdo Do, Ramyar Molania, Paul L. Mitchell, Rita Vaiskunaite, John D. Murdoch, and Alexander Dobrovic Source: Clinical Chemistry 63:9 000–000 (2017) Molecular Diagnostics and Genetics 000–000 (2017), doi:10.1373/clinchem.2017.271932

ColoScape™ offers high sensitivity and accuracy of detection for clinically validated colorectal cancer mutations in DNA extracted from solid tumor, plasma or stool samples.

California-based molecular diagnostics company DiaCarta, Inc., has received a SBIR contract from the National Cancer Institute (NCI). This contract will fund a collaborative program between DiaCarta and University of Florida Health Cancer Center to convert RadTox QuantiDNATM into a cutting-edge test that monitors radiation response in cancer patients.

DiaCarta today announced the introduction of QFusionTM RT-qPCR assay, a new product for the comprehensive, rapid and reliable detection of ALK fusion gene variants. The assay enables users to detect ten EML4-ALK and three KIF5B-ALK fusion gene variants in a single tube of multiplexed reactions with only 50 ng of RNA from FFPE samples in approximately 1.5 hours.

DiaCarta, an innovator in precision molecular diagnostics, today announced that the company has received ISO 13485:2003 certification for the design, manufacture and distribution of its diagnostic and molecular genetic testing kits.

DiaCarta and Pangaea Biotech S.L have signed a long term agreement to launch in the U.S.A and China a non-invasive test to detect genetic material in blood of cancer patients, a technique known as ‘liquid biopsy’.

DiaCarta, an innovative translational genomics and precision molecular diagnostics company, today announced that DiaCarta Clinical Services Laboratory (DCSL) successfully passed the State of California survey under the Clinical Laboratory Improvement Amendments of 1988 (CLIA).

DIACARTA INC. ("DIACARTA") and UNIVERSITY OF POTSDAM (Germany) today announced that the parties have entered into an exclusive license agreement for the development and commercialization of non-invasive early detection of colon cancer from stool samples.

DiaCarta, Inc. raised $8 million in Series A financing from BVCF (BioVeda China Fund). Proceeds from Series A financing will be used to expand the product portfolio and support global commercialization. Dr. Weixin Xu of BVCF will join DiaCarta board of directors.

DiaCarta Inc., a technology driven translational genomics and molecular diagnostics company, today announced it has received CE Mark for its proprietary IVD cancer mutation tests QClamp™ KRAS including codon 146 and 117, NRAS including codon 146, EGFR including T790M, all deletions and insertions, BRAF, JAK2 and PIK3CA. These highly sensitive mutation tests suppress PCR amplification of wild-type template DNA and allows selective PCR amplification of only mutant templates, which can derive results in 2 hours directly from samples including FFPE and liquid biopsy without DNA purification on any commercial available Real-Time PCR machines.

DiaCarta today announced it has launched its QClamp™ somatic mutation tests, highly sensitive and rapid tests for KRAS, NRAS, EGFR, BRAF, PIK3CA and more in 2 hours without DNA extraction.